eviprostat®-S
sabal serrulatum 320mg UNO
The active components from the fruit of saw palmetto relieve the urinary symptoms caused by benign prostatic enlargement
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Herbal approach to improve urinating complaints due to benign prostatic hyperplasia (BPH).
- Well-tolerated herbal product ameliorates the typical urinary symptoms caused by BPH.
- Reduces swelling and inflammation of the prostate tissue.
- Effectively reduces the urge to urinate, improves difficult urination and strengthens the urinary stream.
- Improves urinary parameters such as flow rates and residual volume.
Principle outcomes of clinical studies of Saw palmetto fruit extracts:
- Saw palmetto provides improvement in urinary symptoms in mild to moderate BPH based on standardised endpoints (IPSS).
- Saw palmetto provides moderate improvement of uroflowmetry parameters and decreases nocturia without increasing serum Prostate-specific antigen (PSA).
- Saw palmetto was reported to be possibly equivalent to the 5 α-reductase inhibitor finasteride (with fewer side effects).
- Saw palmetto was reported to be possibly equivalent to the α-blocking agent tamsulosin (with fewer side effects).
Several experimental finding (in vitro and in vivo) support the plausibility of use of Saw palmetto fruit extract in BPH.
Anti-androgenic effects
Inhibition of a receptor binding
Anti-proliferative effect
Anti-spasmolytic effect
Anti-inflammatory effect
Anti-androgenic effects
- Inhibition of the activity of 5 α-reductase, an enzyme converting testosterone into the active compound DHT, in prostatic epithelium and stroma.
- Inhibition of prostatic growth in athymic nude mice, in which human benign hyperplastic prostatic tissue had been transplanted.
Inhibition of a receptor binding
- Inhibition of tamsulosin binding to human α1 adrenoceptors (non competitive).
Anti-proliferative effect
- Significant inhibition of proliferation and introduction of cell death in human BPH tissue from patients (both epithelium and stroma).
- Reduction of weight of the prostate in castrated rats and mice treated with testosterone.
Anti-spasmolytic effect
- Relaxing tonic contractions induced by vanadate, noradrenalin etc. in various smooth muscle preparations.
- Inhibition of calmodulin-dependent cAMP phosphodiesterse activity.
Anti-inflammatory effect
- Inhibiting the production of leukotriene B4.
- Suppressing the calcium ionophore-stimulated synthesis of thromboxane B2.
Mandatory Information
Eviprostat-S sabal serrulatum 320mg UNO
Area of application:
For improvement of prostate-dependent disorders during urination due to benign enlargement of the prostate (micturition disorders due to benign prostate hyperplasia stadium I to II acc. to Alken resp. II to III acc. to Vahlensieck).
For risks and side effects, please ask your doctor or pharmacist
